RPE65

Across TCGA patient cohorts, RPE65 mutation is significantly associated with the RNA expression of many other genes, with 4,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPE65-associated genes across cancer lineages are ZNF280B, MIR6090, and SNORD116-23. Each is linked with RPE65 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPE65-to-partner and partner-to-RPE65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF280B grouped by RPE65-low versus RPE65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPE65→partner) and Y-score (partner→RPE65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF280B →	+0.607	+2.403	<.001	<.001	3	3
SKCM	MIR6090 →	+0.157	+2.089	.001	.008	3	3
BRCA	SNORD116-23 →	+0.594	+4.924	<.001	.002	3	3
UCEC	CRYBB2P1 →	+0.465	+2.413	.001	<.001	3	3
UCEC	MICALL1 →	+0.442	+2.238	.004	.006	3	3
LUAD	CENPM →	+1.031	+3.345	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,578 associations by consensus.

ZNF280B by RPE65 expression — UCEC

Explore this box plot interactively →