RPE65

Across TCGA patient cohorts, RPE65 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPE65-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and PDCD4. Each is linked with RPE65 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPE65-to-partner and partner-to-RPE65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by RPE65-low versus RPE65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPE65→partner) and Y-score (partner→RPE65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.417	+3.321	.042	.009	3	3
UCEC	JNK_pT183_Y185 →	-0.153	-2.459	.017	.018	3	3
UCEC	PDCD4 →	-0.737	-2.584	<.001	.001	3	3
UCEC	eEF2 →	+0.277	+1.678	.043	.023	3	2
UCEC	EGFR_pY1068 →	-0.274	-2.700	.004	.005	3	2
UCEC	FoxM1 →	+0.226	+2.087	.022	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

GAPDH by RPE65 expression — UCEC

Explore this box plot interactively →