RPE65

Across TCGA cell cohorts, RPE65 RNA expression is significantly associated with the go_rna of many other GO terms, with 389 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPE65-associated GO terms across cancer lineages are Host-mediated activation of viral process, Phenol-containing compound metabolic process, and Sphingomyelin metabolic process. Each is linked with RPE65 in more than 4 cancer types. Because this analysis shows association rather than direction, both RPE65-to-partner and partner-to-RPE65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Host-mediated activation of viral process grouped by RPE65-low versus RPE65-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPE65→partner) and Y-score (partner→RPE65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Host-mediated activation of viral process →	+0.065	+0.163	.002	.005	3	5
LARGE_INTESTINE	Phenol-containing compound metabolic process →	-0.059	-0.062	.001	.002	3	4
STOMACH	Sphingomyelin metabolic process →	+0.112	+0.040	<.001	.007	3	4
BLOOD_Lymphoma	Regulation of vascular associated smooth muscle contraction →	-0.169	-0.006	<.001	.003	3	3
BLOOD_Lymphoma	Determination of left/right asymmetry in lateral mesoderm →	+0.134	+0.004	.001	.004	3	3
CNS	ER-nucleus signaling pathway →	+0.083	+0.332	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 389 associations by consensus.

Host-mediated activation of viral process by RPE65 expression — PANCREAS

Explore this box plot interactively →