RPAP3

Across TCGA patient cohorts, RPAP3 mutation is significantly associated with the RNA expression of many other genes, with 1,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPAP3-associated genes across cancer lineages are CA15P2, RNU6-236P, and SSXP9. Each is linked with RPAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPAP3-to-partner and partner-to-RPAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA15P2 grouped by RPAP3-low versus RPAP3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPAP3→partner) and Y-score (partner→RPAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CA15P2 →	+0.063	+5.122	<.001	.008	3	2
UCEC	RNU6-236P →	+0.282	+1.945	.001	.002	3	2
LUSC	SSXP9 →	+0.112	+5.272	<.001	.001	3	2
LUAD	RNU6-952P →	+0.386	+5.631	<.001	.004	3	2
UCEC	H4C1 →	+0.555	+2.526	.002	.001	3	2
UCEC	SMIM34B →	+0.011	+3.834	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,122 associations by consensus.

CA15P2 by RPAP3 expression — BRCA

Explore this box plot interactively →