RPAP3

Across TCGA pan-cancer cohorts, RPAP3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RPAP3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPAP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPAP3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and LUSC are the cancer types where RPAP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPAP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.731	<.001	12	view →
LIHC	Female	II,III,IV	+0.876	<.001	9	view →
LUSC	Male	II,III,IV	+0.829	<.001	8	view →
BRCA	All	III,IV	+0.598	<.001	8	view →
BLCA	All	All	+0.509	<.001	8	view →
LUAD	Male	II,III,IV	+0.746	<.001	7	view →
STAD	All	II,III,IV	+0.723	<.001	7	view →
THCA	All	All	−0.256	<.001	6	view →
CHOL	Male	All	+1.531	<.001	5	view →
KICH	All	All	−0.603	<.001	4	view →
COAD	Male	II,III,IV	+0.555	<.001	4	view →
KIRP	All	II,III,IV	+0.395	.031	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RPAP3–HNSC

Open the HNSC breakdown →