Across TCGA patient cohorts, RPA4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPA4-associated genes across cancer lineages are INPP4B, Stathmin, and Caspase-8. Each is linked with RPA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPA4-to-partner and partner-to-RPA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA4→partner) and Y-score (partner→RPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.323	-3.584	.006	.002	3	2
UCEC	Stathmin →	+0.101	+1.763	.046	.048	3	2
UCEC	Caspase-8 →	-0.233	-3.780	.011	<.001	3	2
UCEC	EGFR_pY1068 →	-0.227	-1.847	.013	.008	3	1
UCEC	Gab2 →	+0.291	+1.847	.026	.008	3	1
UCEC	JNK_pT183_Y185 →	-0.135	-1.700	.029	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

RPA4 survival (RNA) · tumor vs normal (RNA) · all RPA4 data types