RP9

Across TCGA patient cohorts, RP9 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RP9-associated genes across cancer lineages are eIF4G, INPP4B, and Ku80. Each is linked with RP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both RP9-to-partner and partner-to-RP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by RP9-low versus RP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP9→partner) and Y-score (partner→RP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.332	+2.999	.021	.035	3	1
UCEC	INPP4B →	-0.304	-2.321	.044	.033	3	1
UCEC	Ku80 →	+0.226	+1.887	.040	.031	3	1
UCEC	MEK1 →	+0.532	+3.700	.001	.001	3	1
UCEC	MSH2 →	-0.331	-2.312	.002	.034	3	1
UCEC	MSH6 →	-0.453	-2.999	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4G by RP9 expression — UCEC

Explore this box plot interactively →