ROS1

Across TCGA patient cohorts, ROS1 mutation is significantly associated with the RNA expression of many other genes, with 8,051 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROS1-associated genes across cancer lineages are RANBP1, IQGAP3, and WDHD1. Each is linked with ROS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ROS1-to-partner and partner-to-ROS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RANBP1 grouped by ROS1-low versus ROS1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROS1→partner) and Y-score (partner→ROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RANBP1 →	+0.586	+2.629	<.001	.005	3	5
STAD	IQGAP3 →	+0.690	+3.472	.007	.002	3	5
LUAD	WDHD1 →	+0.709	+2.819	.002	.001	3	5
UCEC	PLA2G12AP1 →	+0.239	+1.308	<.001	<.001	3	5
LUAD	HNRNPA3 →	+0.371	+3.213	.005	.009	3	5
UCEC	VRK1 →	+0.414	+1.967	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,051 associations by consensus.

RANBP1 by ROS1 expression — LUAD

Explore this box plot interactively →