ROS1

Across TCGA pan-cancer cohorts, ROS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ROS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ROS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ROS1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where ROS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.428	<.001	12	view →
KIRC	Female	All	−1.003	<.001	10	view →
HNSC	All	All	+0.758	<.001	10	view →
LUAD	Male	II,III,IV	−2.123	<.001	9	view →
KICH	Female	II,III,IV	−1.017	<.001	8	view →
LUSC	Male	II,III,IV	−3.606	<.001	7	view →
KIRP	Male	All	−0.635	<.001	6	view →
BLCA	All	III,IV	+0.268	.010	5	view →
LIHC	All	All	+0.192	.001	5	view →
BRCA	Female	All	+0.122	.011	4	view →
STAD	All	All	+0.233	.010	3	view →
PRAD	All	All	−0.202	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ROS1–COAD

Open the COAD breakdown →