ROS1

Across TCGA patient cohorts, ROS1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROS1-associated genes across cancer lineages are eEF2, 4E-BP1, and INPP4B. Each is linked with ROS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ROS1-to-partner and partner-to-ROS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ROS1-low versus ROS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROS1→partner) and Y-score (partner→ROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.251	+2.841	.016	.033	3	4
STAD	4E-BP1 →	+0.340	+3.321	.005	.009	3	4
COAD	INPP4B →	-0.363	-1.874	.005	.047	3	4
COAD	TIGAR →	+0.308	+1.593	.028	.022	3	4
BLCA	Mre11 →	-0.106	-1.700	.035	.043	3	3
BLCA	p90 RSK →	+0.169	+2.222	.049	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

eEF2 by ROS1 expression — COAD

Explore this box plot interactively →