ROS1

Across TCGA cell cohorts, ROS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,709 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ROS1-associated GO terms across cancer lineages are Positive regulation of hair follicle maturation, L-amino acid metabolic process, and Response to acetaldehyde. Each is linked with ROS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ROS1-to-partner and partner-to-ROS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of hair follicle maturation grouped by ROS1-low versus ROS1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ROS1→partner) and Y-score (partner→ROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of hair follicle maturation →	+0.786	+0.842	.001	<.001	3	7
CNS	L-amino acid metabolic process →	-0.048	-0.844	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Response to acetaldehyde →	+0.286	+0.728	.003	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Cellular response to acetaldehyde →	+0.286	+0.728	.003	.002	3	6
CNS	Regulation of cytokine-mediated signaling pathway →	+0.055	+1.232	<.001	<.001	3	6
LIVER	Negative regulation of G1/S transition of mitotic cell cycle →	+0.101	+1.723	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,709 associations by consensus.

Positive regulation of hair follicle maturation by ROS1 expression — BREAST

Explore this box plot interactively →