ROS1

Across TCGA cell cohorts, ROS1 mutation is significantly associated with the RNA expression of many other genes, with 514 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROS1-associated genes across cancer lineages are CD300LB, CRISP2, and CT45A8. Each is linked with ROS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROS1-to-partner and partner-to-ROS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300LB grouped by ROS1-low versus ROS1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROS1→partner) and Y-score (partner→ROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD300LB →	+0.006	+4.017	<.001	.007	3	2
SOFT_TISSUE	CRISP2 →	+0.086	+3.297	<.001	.008	3	2
SOFT_TISSUE	CT45A8 →	+0.703	+3.459	.005	.003	3	2
BLOOD_Leukemia	C8orf74 →	+0.020	+2.889	<.001	.002	3	2
BLOOD_Lymphoma	XAGE5 →	+0.398	+4.643	<.001	<.001	3	2
LUNG_SCLC	RRP36 →	+0.394	+2.459	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 514 associations by consensus.

CD300LB by ROS1 expression — OESOPHAGUS

Explore this box plot interactively →