RORA-AS1

Across TCGA pan-cancer cohorts, RORA-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RORA-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RORA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RORA-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCEC show a favorable association.

KIRP, PAAD, and UCEC are the cancer types where RORA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.266	0.724	<.001	84	view →
PAAD	DFS	Median	All	0.384	0.175	<.001	60	view →
UCEC	OS	Median	III,IV	0.734	0.444	.003	36	view →
MESO	OS	Quartile	All	0.662	0.425	.006	33	view →
ACC	DFS	Quartile	All	0.403	0.785	.006	29	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	24	view →
LGG	OS	Tertile	All	0.325	0.514	.002	24	view →
STAD	OS	Quartile	All	0.761	0.635	.016	17	view →
GBM	DFS	Quartile	All	0.291	0.164	.008	15	view →
BRCA	DFS	Tertile	III,IV	0.929	0.802	.008	14	view →
UCS	DFS	Quartile	II,III,IV	0.542	0.083	.028	6	view →
LAML	DFS	Median	All	0.563	0.357	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RORA-AS1–KIRP (DFS)

Open the KIRP breakdown →