RORA-AS1

Across TCGA pan-cancer cohorts, RORA-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RORA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RORA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RORA-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where RORA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RORA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.271	<.001	12	view →
THCA	Female	II,III,IV	−0.376	<.001	10	view →
HNSC	Male	III,IV	+0.216	<.001	8	view →
BLCA	Male	All	+0.373	.002	6	view →
KIRP	Male	All	−0.280	<.001	6	view →
BRCA	All	All	+0.207	.004	6	view →
LIHC	Female	II,III,IV	+0.140	<.001	6	view →
LUSC	All	All	+0.187	<.001	5	view →
KICH	All	All	−0.360	<.001	4	view →
STAD	All	II,III,IV	+0.305	.004	3	view →
CHOL	All	All	+0.328	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RORA-AS1–KIRC

Open the KIRC breakdown →