ROR2

Across TCGA patient cohorts, ROR2 mutation is significantly associated with the RNA expression of many other genes, with 4,710 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROR2-associated genes across cancer lineages are FAM136A, ALKBH1, and SAR1A. Each is linked with ROR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ROR2-to-partner and partner-to-ROR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM136A grouped by ROR2-low versus ROR2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROR2→partner) and Y-score (partner→ROR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FAM136A →	+0.431	+3.750	.006	<.001	3	6
UCEC	ALKBH1 →	+0.260	+1.821	.005	.003	3	6
STAD	SAR1A →	+0.379	+3.700	.004	.001	3	5
UCEC	BRCA1 →	+0.445	+1.494	.001	.001	3	5
STAD	RPAP2 →	+0.411	+3.203	.001	.009	3	5
COAD	MKI67 →	+0.599	+2.817	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,710 associations by consensus.

FAM136A by ROR2 expression — STAD

Explore this box plot interactively →