ROR2

Across TCGA pan-cancer cohorts, ROR2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ROR2 data layer compared with 10 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ROR2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ROR2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

LGG, KIRP, and SCLC are the cancer types where ROR2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.353	0.543	<.001	54	view →
KIRP	OS	Median	III,IV	0.184	0.785	.001	51	view →
SCLC	DFS	Tertile	III,IV	0.769	0.329	.002	47	view →
THCA	OS	Tertile	All	0.972	1.000	.001	41	view →
KIRC	DFS	Quartile	All	0.561	0.726	.002	33	view →
DLBC	DFS	Tertile	All	1.000	0.311	.005	29	view →
CHOL	DFS	Median	All	0.657	0.188	.003	23	view →
BLCA	DFS	Quartile	II,III,IV	0.300	0.485	.005	21	view →
UVM	OS	Median	II,III,IV	0.695	0.903	.011	19	view →
MESO	OS	Tertile	All	0.525	0.322	.019	18	view →
STAD	OS	Quartile	All	0.510	0.675	.012	18	view →
PAAD	OS	Median	II,III,IV	0.647	0.452	.009	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ROR2–LGG (OS)

Open the LGG breakdown →