ROR2

Across TCGA patient cohorts, ROR2 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROR2-associated genes across cancer lineages are Cyclin-E2, Caspase-7-cleavedD198, and ER-alpha. Each is linked with ROR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ROR2-to-partner and partner-to-ROR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ROR2-low versus ROR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROR2→partner) and Y-score (partner→ROR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.191	+2.832	.026	.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.056	+2.000	<.001	.029	3	4
STAD	ER-alpha →	-0.198	-2.438	.007	.019	3	3
STAD	ASNS →	+0.392	+3.584	.041	.002	3	3
UCEC	4E-BP1 →	+0.299	+3.700	<.001	.001	3	3
LUSC	FASN →	+0.686	+3.009	.002	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Cyclin-E2 by ROR2 expression — COAD

Explore this box plot interactively →