ROPN1L

Across TCGA patient cohorts, ROPN1L mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROPN1L-associated genes across cancer lineages are MSH2, ATM, and PCNA. Each is linked with ROPN1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ROPN1L-to-partner and partner-to-ROPN1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ROPN1L-low versus ROPN1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROPN1L→partner) and Y-score (partner→ROPN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.341	-2.973	.004	.035	3	1
UCEC	ATM →	-0.556	-3.321	.019	.010	3	1
UCEC	PCNA →	+0.261	+3.321	.021	.010	1	2
UCEC	p27_pT198 →	+0.147	+3.321	.008	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MSH2 by ROPN1L expression — UCEC

Explore this box plot interactively →