ROPN1B

Across TCGA patient cohorts, ROPN1B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROPN1B-associated genes across cancer lineages are eEF2, GSK3-a-b, and ATM. Each is linked with ROPN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ROPN1B-to-partner and partner-to-ROPN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ROPN1B-low versus ROPN1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROPN1B→partner) and Y-score (partner→ROPN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.441	+3.169	.006	.018	3	2
UCEC	GSK3-a-b →	+0.144	+3.169	.018	.018	3	2
UCEC	ATM →	-0.449	-2.986	.028	.035	3	2
UCEC	EGFR_pY1068 →	-0.338	-2.700	.002	.006	3	1
UCEC	IGFBP2 →	-0.591	-3.000	.043	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-1.986	.006	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eEF2 by ROPN1B expression — UCEC

Explore this box plot interactively →