ROPN1B

Across TCGA pan-cancer cohorts, ROPN1B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ROPN1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ROPN1B RNA is repressed in tumor relative to normal tissue. In most cancer types ROPN1B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BRCA are the cancer types where ROPN1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROPN1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.158	<.001	12	view →
THCA	Male	All	−0.687	<.001	11	view →
BRCA	All	III,IV	−1.946	<.001	8	view →
KICH	All	All	−0.141	<.001	6	view →
HNSC	All	II,III,IV	−0.376	.006	4	view →
PRAD	All	All	+0.656	<.001	2	view →
ESCA	All	II,III,IV	+0.315	.017	2	view →
LIHC	All	All	+0.165	.041	1	view →
CHOL	All	All	−0.137	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ROPN1B–KIRC

Open the KIRC breakdown →