ROPN1B

Across TCGA cell cohorts, ROPN1B mutation is significantly associated with the mutation status of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROPN1B-associated genes across cancer lineages are ESRP2, HYAL4, and CDK15. Each is linked with ROPN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ROPN1B-to-partner and partner-to-ROPN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESRP2 grouped by ROPN1B-low versus ROPN1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROPN1B→partner) and Y-score (partner→ROPN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESRP2 →	+3.672	+4.799	.002	.002	1	2
SKIN	HYAL4 →	+4.824	+5.392	.004	.004	1	2
LARGE_INTESTINE	CDK15 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	JMJD8 →	+5.087	+4.523	.006	.006	1	2
SKIN	SFTPA2 →	+4.824	+5.392	.004	.004	1	2
LARGE_INTESTINE	NFX1 →	+2.865	+4.217	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

ESRP2 by ROPN1B expression — LARGE_INTESTINE

Explore this box plot interactively →