ROPN1

Across TCGA patient cohorts, ROPN1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROPN1-associated genes across cancer lineages are p62 Lck ligand, Caspase-8, and 14-3-3_beta. Each is linked with ROPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROPN1-to-partner and partner-to-ROPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ROPN1-low versus ROPN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROPN1→partner) and Y-score (partner→ROPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.522	+2.662	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.253	-2.169	.007	.003	3	2
UCEC	14-3-3_beta →	-0.133	-2.301	<.001	.005	3	1
UCEC	eEF2 →	+0.312	+1.415	.020	.046	3	1
UCEC	EGFR_pY1068 →	-0.305	-2.906	.001	.001	3	1
UCEC	eIF4E →	+0.228	+3.807	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

p62 Lck ligand by ROPN1 expression — UCEC

Explore this box plot interactively →