ROPN1

Across TCGA pan-cancer cohorts, ROPN1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ROPN1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ROPN1 RNA is repressed in tumor relative to normal tissue. In most cancer types ROPN1 is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

BRCA, COAD, and READ are the cancer types where ROPN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROPN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−1.753	<.001	8	view →
COAD	All	IV	−0.295	<.001	8	view →
READ	All	II,III,IV	−0.580	<.001	7	view →
THCA	All	All	−0.021	<.001	5	view →
KICH	All	All	−0.019	<.001	5	view →
HNSC	All	II,III,IV	−0.225	.013	4	view →
LUSC	All	All	+0.123	.012	2	view →
KIRP	Male	All	+0.082	.016	2	view →
LUAD	All	All	+0.022	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ROPN1–BRCA

Open the BRCA breakdown →