ROGDI

Across TCGA patient cohorts, ROGDI mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROGDI-associated genes across cancer lineages are HNRNPDP2, MIR4436B1, and RNU4-58P. Each is linked with ROGDI in more than 1 cancer types. Because this analysis shows association rather than direction, both ROGDI-to-partner and partner-to-ROGDI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPDP2 grouped by ROGDI-low versus ROGDI-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROGDI→partner) and Y-score (partner→ROGDI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HNRNPDP2 →	+0.044	+7.930	<.001	.008	3	2
STAD	MIR4436B1 →	+0.376	+5.187	<.001	.007	3	2
BLCA	RNU4-58P →	+0.335	+5.106	<.001	.008	3	2
BLCA	RNU6-698P →	+1.027	+5.177	<.001	.007	3	2
UCEC	RNU2-14P →	+0.173	+2.455	<.001	.003	3	2
UCEC	RNU6-358P →	+0.269	+2.455	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

HNRNPDP2 by ROGDI expression — LUAD

Explore this box plot interactively →