ROCR

Across TCGA pan-cancer cohorts, ROCR RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ROCR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ROCR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ROCR is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

KIRC, THCA, and BRCA are the cancer types where ROCR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROCR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.169	<.001	9	view →
THCA	Male	All	−0.264	<.001	7	view →
BRCA	All	III,IV	−3.403	<.001	6	view →
HNSC	All	II,III,IV	−0.719	<.001	4	view →
LIHC	Female	All	−0.237	<.001	3	view →
PAAD	Male	All	−0.935	.044	2	view →
LUSC	All	All	+0.133	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ROCR–KIRC

Open the KIRC breakdown →