ROCK2

Across TCGA patient cohorts, ROCK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,419 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ROCK2-associated proteins across cancer lineages are CD74, EVI2B_S268, and EVL_S246. Each is linked with ROCK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ROCK2-to-partner and partner-to-ROCK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ROCK2 versus CD74 in COAD, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK2→partner) and Y-score (partner→ROCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD74 →	-0.452	-0.438	.002	.003	3	6
LSCC	EVI2B_S268 →	-1.076	-0.553	<.001	<.001	3	5
LSCC	EVL_S246 →	-0.709	-0.416	<.001	.001	3	5
LSCC	PTPRC →	-0.712	-0.656	<.001	<.001	3	5
HNSC	HNRNPLL →	+0.289	+0.509	<.001	<.001	3	5
LSCC	ASAP2 →	+0.408	+0.653	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,419 associations by consensus.

ROCK2 vs CD74 — COAD

Explore this scatter interactively →