ROCK2

Across TCGA pan-cancer cohorts, ROCK2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ROCK2 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ROCK2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ROCK2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

CESC, KIRP, and KIRC are the cancer types where ROCK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.410	0.685	<.001	84	view →
KIRP	DFS	Tertile	All	0.600	0.797	<.001	78	view →
KIRC	OS	Tertile	All	0.735	0.535	<.001	69	view →
ACC	DFS	Quartile	All	0.305	0.830	<.001	52	view →
KICH	DFS	Tertile	III,IV	0.332	1.000	.001	44	view →
LGG	OS	Tertile	All	0.715	0.869	<.001	32	view →
UCS	DFS	Tertile	IV	0.978	0.239	.024	30	view →
BLCA	DFS	Median	All	0.166	0.515	.001	28	view →
LIHC	OS	Quartile	All	0.639	0.859	.001	24	view →
COAD	OS	Quartile	IV	0.872	0.396	.003	23	view →
UVM	DFS	Median	III,IV	0.292	0.749	.013	17	view →
THYM	DFS	Median	III,IV	1.000	0.402	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ROCK2–CESC (DFS)

Open the CESC breakdown →