ROCK2

Across TCGA patient cohorts, ROCK2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,869 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ROCK2-associated genes across cancer lineages are CHMP3, ITGB1BP1, and ASAP2. Each is linked with ROCK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ROCK2-to-partner and partner-to-ROCK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ROCK2 versus CHMP3 in LUAD, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK2→partner) and Y-score (partner→ROCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHMP3 →	+0.396	+0.197	.001	<.001	3	5
HNSC	ITGB1BP1 →	+0.589	+0.221	.003	.002	3	5
HNSC	ASAP2 →	+0.829	+0.249	<.001	<.001	3	5
CCRCC	COX7A1 →	+1.105	+0.141	<.001	<.001	3	5
BRCA	PABPC5 →	+0.692	+0.229	.003	.001	3	5
OV	LINC01936 →	+0.645	+0.168	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,869 associations by consensus.

ROCK2 vs CHMP3 — LUAD

Explore this scatter interactively →