ROCK2

Across TCGA patient cohorts, ROCK2 mutation is significantly associated with the RNA expression of many other genes, with 3,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROCK2-associated genes across cancer lineages are LINC01072, GOT1, and RNA5SP297. Each is linked with ROCK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROCK2-to-partner and partner-to-ROCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by ROCK2-low versus ROCK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK2→partner) and Y-score (partner→ROCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01072 →	+0.067	+1.449	.004	.007	3	3
UCEC	GOT1 →	+0.387	+2.312	<.001	<.001	3	3
READ	RNA5SP297 →	+0.310	+4.653	<.001	.007	3	3
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	3
COAD	H2AC19 →	+0.109	+3.869	.001	<.001	3	3
UCEC	MIR320A →	+0.404	+1.226	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,512 associations by consensus.

LINC01072 by ROCK2 expression — UCEC

Explore this box plot interactively →