ROCK2

Across TCGA patient cohorts, ROCK2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROCK2-associated genes across cancer lineages are GAPDH, STAT3_pY705, and ATM. Each is linked with ROCK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROCK2-to-partner and partner-to-ROCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ROCK2-low versus ROCK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK2→partner) and Y-score (partner→ROCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.334	+1.765	.030	.011	3	3
UCEC	STAT3_pY705 →	-0.254	-0.999	<.001	.042	3	3
UCEC	ATM →	-0.401	-1.536	.002	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.715	+2.157	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.192	-1.536	.007	.002	3	2
UCEC	eIF4E →	+0.164	+3.820	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GAPDH by ROCK2 expression — UCEC

Explore this box plot interactively →