ROCK2

Across TCGA cell cohorts, ROCK2 mutation is significantly associated with the RNA expression of many other genes, with 1,057 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROCK2-associated genes across cancer lineages are CLEC4D, PNLIPRP1, and SRMS. Each is linked with ROCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROCK2-to-partner and partner-to-ROCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC4D grouped by ROCK2-low versus ROCK2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK2→partner) and Y-score (partner→ROCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CLEC4D →	+0.011	+3.459	.007	.006	3	2
CNS	PNLIPRP1 →	+0.202	+4.321	<.001	<.001	3	2
LARGE_INTESTINE	SRMS →	+0.820	+2.743	.001	.001	3	2
CNS	SMYD1 →	+1.081	+3.807	<.001	.007	3	1
CNS	CRYGC →	+0.489	+3.584	<.001	.003	3	1
CNS	PTCHD3 →	+0.204	+3.700	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,057 associations by consensus.

CLEC4D by ROCK2 expression — CNS

Explore this box plot interactively →