ROBO3

Across TCGA patient cohorts, ROBO3 protein abundance is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ROBO3-associated genes across cancer lineages are SLC5A1, NAA10, and TRMT1. Each is linked with ROBO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROBO3-to-partner and partner-to-ROBO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ROBO3 versus SLC5A1 in GBM, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO3→partner) and Y-score (partner→ROBO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC5A1 →	+0.097	+0.347	<.001	<.001	3	1
GBM	NAA10 →	-0.316	-0.318	.009	.004	3	1
GBM	TRMT1 →	-0.533	-0.386	.001	.002	3	1
GBM	GRWD1 →	-0.486	-0.318	.008	.004	3	1
GBM	SLC16A6 →	+1.057	+0.347	.002	<.001	3	1
GBM	LOX →	+1.372	+0.347	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

ROBO3 vs SLC5A1 — GBM

Explore this scatter interactively →