ROBO3

Across TCGA patient cohorts, ROBO3 mutation is significantly associated with the RNA expression of many other genes, with 6,388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROBO3-associated genes across cancer lineages are HELLS, DEPDC1, and LILRB2. Each is linked with ROBO3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ROBO3-to-partner and partner-to-ROBO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELLS grouped by ROBO3-low versus ROBO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO3→partner) and Y-score (partner→ROBO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HELLS →	+0.481	+1.436	<.001	.001	3	5
UCEC	DEPDC1 →	+0.561	+1.595	<.001	<.001	3	5
COAD	LILRB2 →	+0.673	+3.335	.003	.005	3	4
COAD	FCGR1A →	+0.733	+2.556	<.001	<.001	3	4
UCEC	SKA1 →	+0.702	+1.970	<.001	<.001	3	4
LUAD	RAD51AP1 →	+0.850	+2.999	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,388 associations by consensus.

HELLS by ROBO3 expression — UCEC

Explore this box plot interactively →