ROBO3

Across TCGA patient cohorts, ROBO3 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROBO3-associated genes across cancer lineages are FoxM1, PCNA, and 4E-BP1. Each is linked with ROBO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROBO3-to-partner and partner-to-ROBO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ROBO3-low versus ROBO3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO3→partner) and Y-score (partner→ROBO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.239	+2.188	.033	.031	3	3
COAD	PCNA →	+0.216	+1.815	.019	.016	3	3
UCEC	4E-BP1 →	+0.349	+4.169	<.001	<.001	3	3
COAD	JNK_pT183_Y185 →	-0.265	-2.115	.006	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.556	+3.008	<.001	<.001	3	3
LUSC	MIG-6 →	+0.114	+2.124	.014	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

FoxM1 by ROBO3 expression — LUSC

Explore this box plot interactively →