ROBO3

Across TCGA cell cohorts, ROBO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,920 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ROBO3-associated GO terms across cancer lineages are Negative regulation of negative chemotaxis, Regulation of negative chemotaxis, and Positive regulation of axon guidance. Each is linked with ROBO3 in more than 15 cancer types. Because this analysis shows association rather than direction, both ROBO3-to-partner and partner-to-ROBO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of negative chemotaxis grouped by ROBO3-low versus ROBO3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO3→partner) and Y-score (partner→ROBO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of negative chemotaxis →	+1.317	+2.795	.001	<.001	3	16
OESOPHAGUS	Regulation of negative chemotaxis →	+1.271	+2.031	<.001	<.001	3	15
URINARY_TRACT	Positive regulation of axon guidance →	+1.429	+2.630	<.001	<.001	3	14
BREAST	Regulation of epidermal growth factor receptor signaling pathway →	+0.058	+1.572	.001	.002	3	11
BLOOD_Lymphoma	Golgi to plasma membrane protein transport →	+0.093	+1.634	<.001	.001	3	11
URINARY_TRACT	Peptidyl-lysine oxidation →	+1.190	+2.297	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,920 associations by consensus.

Negative regulation of negative chemotaxis by ROBO3 expression — URINARY_TRACT

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