ROBO3

Across TCGA cell cohorts, ROBO3 mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROBO3-associated genes across cancer lineages are GNPNAT1, ALKBH1, and GRPEL1. Each is linked with ROBO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROBO3-to-partner and partner-to-ROBO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by ROBO3-low versus ROBO3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO3→partner) and Y-score (partner→ROBO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNPNAT1 →	+0.664	+2.714	<.001	.002	3	2
LARGE_INTESTINE	ALKBH1 →	+0.417	+2.628	<.001	.002	3	2
LARGE_INTESTINE	GRPEL1 →	+0.563	+3.321	<.001	.003	3	2
LARGE_INTESTINE	MRPL39 →	+0.647	+2.628	<.001	.002	3	2
LARGE_INTESTINE	EXD2 →	+0.601	+2.350	<.001	.008	3	2
LARGE_INTESTINE	RTRAF →	+0.497	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

GNPNAT1 by ROBO3 expression — LARGE_INTESTINE

Explore this box plot interactively →