Across TCGA cell cohorts, ROBO2 mutation is significantly associated with the RNA expression of many other genes, with 1,013 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROBO2-associated genes across cancer lineages are KHDC3L, CHAC2, and ATOX1. Each is linked with ROBO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROBO2-to-partner and partner-to-ROBO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO2→partner) and Y-score (partner→ROBO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.100	+2.774	.001	<.001	3	3
LARGE_INTESTINE	CHAC2 →	+0.690	+1.949	<.001	.002	3	3
LARGE_INTESTINE	ATOX1 →	-0.587	-1.863	.003	.006	3	3
BONE	TBATA →	+0.028	+4.672	<.001	.001	3	2
PANCREAS	PRSS48 →	+0.073	+3.700	<.001	.008	3	2
BLOOD_Leukemia	FNBP1L →	+1.230	+3.228	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,013 associations by consensus.

Exploration

ROBO2 survival (RNA) · tumor vs normal (RNA) · all ROBO2 data types