Across TCGA pan-cancer cohorts, RNY4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNY4’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where RNY4 RNA is repressed in tumor relative to normal tissue. In most cancer types RNY4 is over-expressed in tumor, although a few such as STAD and KICH show the opposite, repressed pattern.
STAD and KICH are the cancer types where RNY4 tumor–normal differential expression is most reproducible.