Across TCGA pan-cancer cohorts, RNY3P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNY3P2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNY3P2 RNA is repressed in tumor relative to normal tissue. In most cancer types RNY3P2 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC and STAD are the cancer types where RNY3P2 tumor–normal differential expression is most reproducible.