RNU7-4P

Across TCGA pan-cancer cohorts, RNU7-4P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNU7-4P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RNU7-4P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU7-4P is over-expressed in tumor, although a few such as KIRP and LUAD show the opposite, repressed pattern.

KIRP, LUAD, and KICH are the cancer types where RNU7-4P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU7-4P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−0.532	.012	5	view →
LUAD	Female	II,III,IV	−0.664	.015	3	view →
KICH	All	All	−0.319	.007	2	view →
LUSC	All	All	−0.215	.028	2	view →
BRCA	All	III,IV	−0.164	.021	2	view →
THCA	Female	All	+0.080	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RNU7-4P–KIRP

Open the KIRP breakdown →