Across TCGA pan-cancer cohorts, RNU7-46P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU7-46P’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where RNU7-46P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU7-46P is over-expressed in tumor.
STAD, BRCA, and LUAD are the cancer types where RNU7-46P tumor–normal differential expression is most reproducible.