Across TCGA pan-cancer cohorts, RNU7-26P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU7-26P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU7-26P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU7-26P is over-expressed in tumor.
BRCA, PRAD, and ESCA are the cancer types where RNU7-26P tumor–normal differential expression is most reproducible.