RNU7-18P

Across TCGA pan-cancer cohorts, RNU7-18P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNU7-18P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU7-18P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU7-18P is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

HNSC, BLCA, and BRCA are the cancer types where RNU7-18P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU7-18P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.459	<.001	11	view →
BLCA	All	All	+0.916	.002	9	view →
BRCA	All	All	+0.260	.017	4	view →
STAD	All	All	+0.584	.006	3	view →
PAAD	Male	All	−1.089	.004	2	view →
COAD	Male	All	+0.611	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RNU7-18P–HNSC

Open the HNSC breakdown →