Across TCGA pan-cancer cohorts, RNU7-12P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU7-12P’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where RNU7-12P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU7-12P is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
STAD, BLCA, and COAD are the cancer types where RNU7-12P tumor–normal differential expression is most reproducible.