Across TCGA pan-cancer cohorts, RNU6ATAC36P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6ATAC36P’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RNU6ATAC36P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6ATAC36P is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.
COAD, THCA, and KIRC are the cancer types where RNU6ATAC36P tumor–normal differential expression is most reproducible.