Across TCGA pan-cancer cohorts, RNU6-9 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-9’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-9 is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

LUAD, LIHC, and READ are the cancer types where RNU6-9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.374	.001	4	view →
LIHC	Male	All	+0.245	<.001	3	view →
READ	All	III,IV	−0.645	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU6-9 RNA expression & survival · all RNU6-9 data types