Across TCGA pan-cancer cohorts, RNU6-888P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-888P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RNU6-888P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-888P is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.
KIRP, PAAD, and KICH are the cancer types where RNU6-888P tumor–normal differential expression is most reproducible.