RNU6-850P

Across TCGA pan-cancer cohorts, RNU6-850P RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNU6-850P’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RNU6-850P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-850P is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, BLCA, and READ are the cancer types where RNU6-850P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-850P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.429	<.001	11	view →
BLCA	Female	III,IV	+1.641	<.001	10	view →
READ	Female	All	+2.809	<.001	7	view →
LIHC	All	II,III,IV	+0.875	<.001	7	view →
KIRP	All	II,III,IV	+1.043	.009	5	view →
KIRC	All	All	+0.514	<.001	5	view →
STAD	All	All	+1.119	.001	4	view →
LUSC	All	All	+0.605	.003	4	view →
CHOL	Male	All	+3.220	<.001	3	view →
ESCA	Female	All	+1.310	.045	3	view →
KICH	Female	All	−1.128	<.001	3	view →
PRAD	All	All	+0.534	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNU6-850P–COAD

Open the COAD breakdown →