Across TCGA patient cohorts, RNU6-614P mutation is significantly associated with the RNA expression of many other genes, with 2,588 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNU6-614P-associated genes across cancer lineages are CYFIP1, PCCA-DT, and F8A2. Each is linked with RNU6-614P in more than 1 cancer types. Because this analysis shows association rather than direction, both RNU6-614P-to-partner and partner-to-RNU6-614P results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNU6-614P→partner) and Y-score (partner→RNU6-614P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYFIP1 →	+0.707	+3.483	<.001	.002	3	1
UCEC	PCCA-DT →	+0.661	+2.721	<.001	.003	3	1
UCEC	F8A2 →	+0.032	+3.235	<.001	.001	3	1
UCEC	STMN1P1 →	+0.564	+2.845	<.001	.004	3	1
UCEC	MIR6747 →	+0.582	+2.205	.003	.003	3	1
UCEC	H2AC14 →	+1.148	+3.716	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,588 associations by consensus.

Exploration

RNU6-614P survival (RNA) · tumor vs normal (RNA) · all RNU6-614P data types