Across TCGA pan-cancer cohorts, RNU6-581P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNU6-581P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU6-581P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-581P is over-expressed in tumor.
BRCA are the cancer types where RNU6-581P tumor–normal differential expression is most reproducible.